Japanese society of Ova Research

Abstract

Vol.40 No.2

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A case report of perforation of the sigmoid colon due to aggravation of intestinal endometriosis during ovarian stimulation
JMOR, 40(2) 49-55, 2023
Department of Obstetrics and Gynecology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

[Introduction] The impact of assisted reproductive technologies on intestinal endometriosis is unclear. Therefore, the pros and cons of continued ovarian stimulation in refractory infertile patients with intestinal endometriosis are unknown. We report a case of intestinal endometriosis that progressed during ovarian stimulation resulting in serious complications. [Case] The patient was 42 years old, gravida 0, para 0. Ovarian stimulation with rFSH/hMG was performed 6 times to obtain 6-cell stage embryos (Veeck classification Grade 3) and 5-cell stage embryos (Grade 3). Subsequently, an embryo transfer was performed, but pregnancy was not achieved, and ovarian stimulation with rFSH/hMG was performed at another hospital. At the time of transfer, the patient had a narrowing of the stool, but this was not reported to the physician. During the sixth ovum pick-up, the patient underwent laparotomy due to stenosis and perforation of the sigmoid colon. After the surgery, the patient gave up fertility treatment. [Discussion] Early diagnosis of intestinal endometriosis without overlooking gastrointestinal symptoms that appear under ovarian stimulation is essential. Even minor lesions without symptoms may develop into serious gastrointestinal complications under ovarian stimulation, and the feasibility of continued ovarian stimulation should be evaluated.

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