Abstract
Vol.40 No.1
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Evaluation of the effect of granulocyte-macrophage colony-stimulating factor in embryo transfer medium
JMOR, 40(1) 21-24, 2023
The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is reportedly relevant to pregnancy. In this study, we compared pregnancy, miscarriage, and live birth rates across on the culture medium used for embryo transfer. We also evaluated the effectiveness of GM-CSF-containing culture medium in single frozen-thawed blastocyst transfer (sFET). Among 362 women, a total of 431 FET cycles resulting in sFET between December 2020 and March 2021 were analyzed (GM-CSF group 230 cycles, control group 201 cycles). The miscarriage rate in the GM-CSF group was lower than in the control group; however, there were no differences in the pregnancy and live birth rates. In the women who had previously experienced at least one miscarriage (GM-CSF group 106 cycles, control group 96 cycles), a significant decrease in the miscarriage rate and an increase in the live birth rate were noted for the GM-CSF group. These results suggest that GM-CSF had a highly significant effect for women who have previously had a miscarriage.
