Japanese society of Ova Research

Abstract

Vol.39 No.2

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Oocyte meiosis abnormalities associated with maternal aging and antioxidants and anti-aging agents effective at improving oocyte quality in IVM
JMOR, 39(2) 81-91, 2022
Mitsuru Nago1,3 Kanon Kubono2 Naoko Kimura1,2* 
1Laboratory of Animal Reproduction, United Graduate School of Agricultural Sciences, Iwate University, 1-23 Wakaba-machi, Tsuruoka, Yamagata 997-8555, Japan, 2Laboratory of Animal Reproduction, Faculty of Agricultural Science, Yamagata University, 1-23 Wakaba-machi, Tsuruoka, Yamagata 997-8555, Japan, 3Denentoshi Ladies Clinic, 1-5-1 Azamino, Aoba-ku, Yokohama, Kanagawa 225-0011, Japan

Maternal ability to produce normal offspring heavily depends on the quality of the oocytes. Therefore, the elucidation of the molecular mechanisms of the various stresses and aging phenomenon that oocytes are subjected to, and technological innovations for anti-aging or the rescue of poor quality oocytes, would contribute to advanced assisted reproductive technologies and livestock productivity, and would also permit the preservation of endangered species. In this paper, we review the literature and evaluate studies that have investigated maternal age-related increases in oocyte aneuploidy and morphological changes in the spindle assembly, the changes in meiotic progression that cause them, and changes in expression of factors that control chromosome segregation focussing on mice, an experimental animal model. We also introduce recent studies that have focused on the improvement of aged oocyte quality (effects of antioxidants and anti-aging agents) using in vitro maturation (IVM).

Keywords: Oocyte  Maternal aging  Meiosis  Aneuploidy  In vitro maturation (IVM) 
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