Abstract
Vol.39 No.2
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Potential clinical applications of melatonin in ovarian aging and assisted reproductive technology
JMOR, 39(2) 65-73, 2022
Melatonin is a neuroendocrine hormone secreted by the pineal gland. In addition to its receptor-mediated actions, melatonin also has strong antioxidant activities, scavenging free radicals such as reactive oxygen species (ROS), and its direct free radical scavenging actions are receptor-independent. ROS play crucial roles in reproductive functions such as the ovulatory process; however, in excess, they may adversely affect oocytes through oxidative stress causing infertility. Melatonin present in follicles may possibly protect oocytes from ROS via its antioxidant activity. Melatonin supplementation improves the outcomes of in vitro fertilization programs for infertile patients by improving oocyte quality, and in general aging, the main cause of ovarian aging is considered to be oxidative stress caused by ROS. Melatonin is receiving attention as an anti-aging hormone, and it may be useful for preventing aging of the ovary. This review describes the relationship between melatonin and human reproductive function, as well as the clinical applications of melatonin which are expected to improve the outcomes of assisted reproductive technology such as IVF, and also discusses the possibilities for melatonin in preventing ovarian aging.
