Abstract
Vol.39 No.1
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Usefulness of supplements for elderly infertile women
JMOR, 39(1) 27-34, 2022
In recent years, with the increase in infertile patients, assisted reproductive technology has made remarkable progress, but unfortunately the pregnancy rate and live birth rate of all infertility patients have not improved. It is thought that this is related to an increase in the desired age of pregnancy among women and an increase in refractory infertility with ovarian dysfunction. According to basic research, excessive oxidative stress due to the accumulation of reactive oxygen species in the process of ovarian aging is detrimental to the environment inside the follicle, causing DNA damage, lipid peroxidation, protein damage and so on. It has been suggested that the quality of oocytes may deteriorate with aging. Therefore, in treatments for elderly infertile patients, supplemental diets, such as antioxidants and hormones, has been prescribed with the expectation of improving the quality of oocytes. This review outlines recent research reports such as preclinical animal and clinical human studies examining the efficacy of various components in supplemental diets administered for age-related ovarian dysfunction.
