Abstract
Vol.39 No.1
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Genome editing for developing disease models in mice
JMOR, 39(1) 9-15, 2022
Disease models using genetically modified animals have contributed to the progress of research in medical science. The conventional method for producing genetically modified mice using embryonic stem (ES) cells is time-consuming. However, genome editing based on the CRISPR-Cas9 system, which was introduced in 2012, enables the efficient introduction of mutations into given genomic regions, and the application of this method to fertilized eggs has dramatically simplified and accelerated the production of genetically modified mice. In this review, we introduce the basics and applications of genome editing technology used to produce disease models with reference to the latest findings.
