Abstract
Vol.36 No.2
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Original
Laboratory and clinical outcomes of oocytes matured from metaphase I to metaphase II on the day of oocyte retrieval in intracytoplasmic sperm injection cycles
JMOR, 36(2) 115-119, 2019
The fertilization outcomes of belatedly matured metaphase II (MII) oocytes that extrude the first polar body a few hours after cumulus cell removal have been investigated. However, the influence of using these oocytes on the outcomes of intracytoplasmic sperm injection (ICSI) remains unclear. Here, we investigated the laboratory and clinical outcomes of ICSI using belatedly matured oocytes on the day of retrieval. The laboratory and clinical outcomes of 10,605 ICSI cycles performed using accurately timed MII oocytes (normal MII group) and belatedly matured oocytes (delayed MII group) between January 2010 and December 2018 were retrospectively investigated. The fertilization rate, proportion of morphologically good-quality embryos on day 3, and proportion of embryos that developed into morphologically good-quality blastocysts by day 5 were significantly lower in the delayed MII group than in the normal MII group. However, no significant differences in clinical outcomes (clinical pregnancy rate, miscarriage rate, live birth rate) were observed for thawed blastocyst transfers between groups the two group. Oocytes that extruded the first polar body a few hours after cumulus cell removal and develop ed into morphologically good-quality blastocysts did not have an adverse effect on the clinical outcomes of ICSI embryos.
