Function of the sperm acrosomal EQUATORIN protein analyzed using genetically modified mice

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Abstract

Vol.36 No.2

Function of the sperm acrosomal EQUATORIN protein analyzed using genetically modified mice

JMOR, 36(2) 71-77, 2019

¹Future Medicine Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, ²Department of Functional Anatomy, Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

Spermatozoa have functional molecules involved in the acrosome reaction and fusion, through to early embryo formation, which transport the paternal genome to the oocyte. The genes encoding these proteins are expressed during spermatogenesis, and then the proteins produced are organized in sperm functional domains. There are many genetically modified mice targeting various functional proteins. Information obtained from the model mice is valuable to understand human reproduction and infertility. In this minireview, we introduce an example of a sperm acrosomal EQUATORIN protein, which is analyzed by using genetically modified mice targeting Eqtn gene and anti-EQUATORIN antibodies.

Keywords: Spermatozoa Acrosome EQUATORIN Genetically modified mouse Infertility

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