Angiogenesis and hormonal regulation on uterine receptivity for blastocyst implantation

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Abstract

Vol.32 No.3

Mini Review

Angiogenesis and hormonal regulation on uterine receptivity for blastocyst implantation

JMOR, 32(3) 79-85, 2015
DOI: 10.1274/jmor.32.79

Hiromichi Matsumoto¹²* Emiko Fukui¹² Midori Yoshizawa^{1, 2}

¹Laboratory of Animal Breeding and Reproduction, Division of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi 321–8505, Japan
²Center for Bioscience Research and Education, Utsunomiya University, Tochigi 321–8505, Japan

Synchronization of embryonic development and differentiation of specific uterine cell types to a receptive state is essential for a successful pregnancy. The period of uterine receptivity for implantation is limited. Increased vascular permeability and angiogenesis are hallmarks of the implantation process. Although implantation involves the interaction of numerous signaling molecules, the hierarchical mechanisms that coordinate the embryo–uterine dialog remain poorly understood. This review highlights our knowledge about angiogenesis, uterine receptivity, and hormonal regulation for blastocyst implantation in the mouse. A better understanding of uterine biology during the peri-implantation period would facilitate the further development of reproductive technology.

Keywords: Angiogenesis Decidualization Implantation Steroid hormones Uterus

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