Changes in Gene Expression Associated with Conceptus Implantation to the Maternal Endometrium

Mini Review

JMOR, 30(1) 2-10, 2013
DOI: 10.1274/jmor.30.2

Kazuhiko Imakawa¹* Jiro Yasuda² Takeshi Kobayashi³⁴ Takayuki Miyazawa³

¹Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
²Departmernt of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
³Laboratory of Signal Transduction, Department of Cell Biology, Institute for Viral Research, Kyoto University, Kyoto 606-8507, Japan
⁴Present address: International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan

Processes of conceptus implantation and placentation vary among mammalian species. However, differences in physiological and biochemical processes were once thought not to differ so much, particularly as to the kinds of genes expressed. In fact, recent progress has identified that in addition to the hormones, cytokines, proteases and cell adhesion molecules classically characterized, epithelial-mesenchymal transition (EMT), epigenetic regulation and the expression of endogenous retroviruses (ERV) are all required for the progression of conceptus implantation to placentation. Thus, continued research into EMT, epigenetic regulation and the expression of ERVs will aid in enhancing understanding of their impact on reproductive physiology in humans and domestic animals.

Keywords: Implantation Mammals Gene expression EMT ERV

Year	equal after before
Volume	equal after before	Number	equal after before
Title		Author
Abstract		Keywords

Content

Abstract

Vol.30 No.1