Abstract
Vol.43 No.2
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The possibility and characteristics of aging/senescence-related change in the uterus
JMOR, 43(2) 107-116, 2026
Aging refers to the passage of time in an individual, whereas senescence describes the progressive decline in tissue and organ function. In recent years, senescence has been increasingly recognized as a potentially controllable process, and research into its mechanisms and interventions is rapidly advancing. Female fertility has declined with a rise in advanced maternal age. While reduced oocyte quality has long been considered the major cause, accumulating evidence suggests that age-related changes in the uterine environment also have a critical role. Indeed, the aging uterus exhibits senescence-associated alterations, including cellular senescence, chronic inflammation, DNA damage, and mitochondrial dysfunction. These age-related changes do not occur independently but interact with one another, leading to impaired endometrial receptivity and disrupted tissue remodeling, ultimately contributing to reduced fertility. A better understanding of uterine senescence (aging) is expected to facilitate the development of novel therapeutic strategies and improve clinical outcomes in the future.
