Abstract
Vol.43 No.1
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Original
Impact of low-level laser irradiation on female mouse fertility
JMOR, 43(1) 61-66, 2026
In this study, we investigated the effects of low-level laser therapy (LLLT) on the reproductive traits of ICR female mice. First, we examined the relationship between age and reproductive performance, and observed that in retired breeders, both the mating rate and total ovulation number decreased. In contrast, the developmental competence of collected fertilized embryos and parthenogenetic embryos was not impaired. Next, we externally irradiated one ovarian region of the same individual mice with LLLT seven times and evaluated their reproductive traits. In retired females, an improvement in oocyte number was observed on the irradiated side compared with the non-irradiated side. We then compared the reproductive traits of LLLT-irradiated and non-irradiated mice. In retired females, the total number of ovulated oocytes per mouse slightly increased following LLLT, but the difference was not significant. When LLLT was applied regularly from 8 to 36 weeks of age, it led to improved mating rates, fertilization rates, and blastocyst formation rates of both fertilized and parthenogenetic embryos. These findings suggest that LLLT may exert beneficial effects on female reproductive function when applied continuously over an extended period.
