Abstract
Vol.43 No.1
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The relationship between chromosomal abnormalities in embryos and developmental kinetics and iDAScore version 2.0
JMOR, 43(1) 39-46, 2026
Preimplantation genetic testing for aneuploidy (PGT-A) has been widely used to increase the success rate of embryo transfer; however, the relationship between PGT-A results and embryonic developmental kinetics and evaluation scores remains unclear. In this study, we compared patient age, developmental kinetics determined by a time-lapse incubator, and the embryonic evaluation score assessed by iDAScore Ver.2.0 with the results of PGT-A. Data from 193 blastocysts from 99 couples who underwent PGT-A at our clinic between January 2020 and May 2024 were used in a retrospective analysis. Compared to aneuploid embryos, embryos assessed as normal by PGT-A were on average derived from younger females, irrespective of the fertilization method (conventional in vitro fertilization or intracytoplasmic sperm injection). Aneuploidy delayed embryonic development and decreased the iDAScore, irrespective of the fertilization method, and the aneuploidy-induced delay in developmental kinetics of embryos derived from aged patients (≧38 years) was more apparent than that of embryos derived from younger patients (<38 years). Aneuploidy patterns (chromosomal increases or decreases) affected the iDAScore Ver.2.0. Overall, a low iDAScore reflected chromosomal abnormalities, but this was not the case for all types of abnormalities.
