Abstract
Vol.43 No.1
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Mastering vitrification in the lab: From the fundamentals to quality management
JMOR, 43(1) 13-21, 2026
With the advancement of cryopreservation techniques, embryo vitrification has become an essential component of assisted reproductive technology. In Japan, a large proportion of neonates born through in vitro fertilisation are derived from frozen embryos. In addition, the introduction of insurance coverage in 2022 has reduced the financial barriers to infertility treatment, thereby increasing the number of patients and the demand for frozen embryo transfer. On the other hand, the number of embryo transfers covered by insurance is limited. Therefore, to maximise pregnancy outcome per embryo transfer, it is crucial to produce and select high-quality embryos, as well as to apply advanced cryopreservation techniques. Furthermore, maintaining a consistent standard of cryopreservation techniques and ensuring stable outcomes requires a proper quality management system. In light of these circumstances, this article presents the principles and protocols of cryopreservation, highlights the significance of implementing quality management to improve and stabilise clinical outcomes, and introduces specific initiatives undertaken at our clinic.
