Abstract
Vol.42 No.1
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Chromosome aberrations in early embryos
JMOR, 42(1) 3-8, 2025
During mitosis, cells maintain a genome containing genetic information in daughter cells through accurate chromosome segregation. However, chromosome aberrations are known to be very common during early mammalian embryogenesis and are thought to cause genetic disorders such as infertility and Down's syndrome. Chromosome segregation abnormalities during early embryogenesis lead to the formation of mosaic embryos, in which cells with normal genomes are mixed with cells with abnormal genomes, but the exact frequency and causes of their formation are not yet known. Understanding these factors may contribute to the treatment of infertility and the study of cell cancer caused by chromosomal aberrations. In this article, we describe the causes of chromosome aberrations in early embryos that we have recently identified and discuss the current status of research and future prospects.
