Japanese society of Ova Research

Abstract

Vol.37 No.1

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Case Report
A case of mature teratoma in the residual ovary after fertility-sparing therapy for ovarian yolk sac tumor managed with oocyte cryopreservation followed by cystectomy
JMOR, 37(1) 43-48, 2020
1 Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan, 2 Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan

Some young women with gynecological diseases undergo salpingo-oophorectomy. However, new ovarian tumors may develop in the remaining ovary at a young age after such treatment. Cystectomy is considered to be effective for fertility preservation. However, if the ovarian tumor is large, the normal ovarian parenchyma cannot be clearly detected in some cases. A 10 year-old patient with yolk sac tumor in the right ovary underwent fertility-sparing therapy. Seven years later, a large mature teratoma in her left ovary was detected. Furthermore, the ovarian parenchyma was not clearly detected by ultrasonography. Cystectomy was decided as the treatment, and the patient hoped for oocyte cryopreservation before laparotomy, in case of iatrogenic ovarian failure after surgery. The patient underwent random-start ovarian hyperstimulation in the luteal phase with dual a dual trigger 2 days prior to surgery. On the scheduled operative day, 10 metapase II oocytes were retrieved under direct observation and cryopreserved. Even though the ovarian parenchyma could not be clearly detected before ovarian stimulation, oocytes could be retrieved under direct observation on the operative day. This approach made it possible to safely retrieve enough metaphase II oocytes for cryopreservation.

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