Abstract
Vol.37 No.1
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Clinical application of stimulation of early-stage follicles through Hippo signal activation: development of Drug-free IVA (In vitro activation)
JMOR, 37(1) 3-8, 2020
In reproductive medicine, different treatments have been established which promote the growth of gonadotropin-dependent antral follicles using endogenous or exogenous gonadotropin treatments. However, there is currently no method which can stimulate the growth of early stage follicles. Therefore, in patients with ovarian dysfunction with decreases in antral follicles, the number of oocytes obtained after ovarian stimulation is limited, leading to difficulty in infertility treatment. Recently, we developed a method to stimulate early follicular growth by regulating the Hippo signaling pathway, which is known as a signal related to mechanobiology, and succeeded in its clinical application. In this review, we introduce our protocol for stimulating early follicular growth which we named "drug-free IVA" and report the clinical outcomes of drug-free IVA in the infertility treatment of patients with ovarian dysfunction.
